Par-4 is an essential downstream target of Dlk in Dlk/Par-4-mediated apoptosis
نویسندگان
چکیده
*Institute of Genetics, University of Bonn, D-53117 Bonn, Germany ‡present address: Institute of Pharmacology and Toxicology, University Hospital of Johann Wolfgang Goethe-University of Frankfurt am Main, D-60590 Frankfurt am Main, Germany §present address: Institute of Health Sciences, Sargent College, Boston University, Boston, MA 02215, USA ||Institute of Structural Biology (IBI-2), Research Center Jülich, D-52425 Jülich, Germany ¶Biochemistry and Cell Biology, School of Engineering and Science, Jacobs University Bremen, D-28759 Bremen, Germany
منابع مشابه
Par-4 is an essential downstream target of DAP-like kinase (Dlk) in Dlk/Par-4-mediated apoptosis.
Prostate apoptosis response-4 (Par-4) was initially identified as a gene product up-regulated in prostate cancer cells undergoing apoptosis. In rat fibroblasts, coexpression of Par-4 and its interaction partner DAP-like kinase (Dlk, which is also known as zipper-interacting protein kinase [ZIPK]) induces relocation of the kinase from the nucleus to the actin filament system, followed by extensi...
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